Of course verse 6 is profitable when isolated and considered separately, but the context in which the statement was made is interesting, namely, the withdrawal from a situation that is perverse and not conducive to spirituality. There are times when we have to show disapproval, and to do so correctly—that is, to know what God likes and what He frowns on—we have to be familiar with His Word. To be able to discern between good and evil is a mark of maturity (Heb. 5:14). The bottom line of success is to make our calling and election sure. Few find the narrow way, and even fewer end up as part of the Bride class.
Verse 6 applies to the servant-master relationship, as well as to other situations, for one is to be content in his circumstance as long as it does not violate conscience. Stated another way, one who is engaged in menial or lowly service should be content with his circumstance because he can serve the Lord equally well whether he is a servant or a master. To realize this contentment keeps one from a fretful spirit in an employment situation or other circumstance of life. “Great gain” is being relieved of anxieties along these lines, for the cares of this life can be a snare.